Clinical Trial

Probiotics Use and Preventing Gastrointestinal Symptoms in People Living With Overweight and Obesity.

Enrolling by Invitation
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Summary
Inflammatory bowel disease (IBD) affects over 6.8 million people worldwide, with current treatments often causing side effects and poor patient compliance. Dysbiosis of gut microbiota is a key factor, and while probiotics are considered safe and beneficial, conventional strains fail to function effectively during active inflammation due to high iron levels in the gut. Streptococcus thermophilus (FX856), unlike traditional probiotics, can thrive in this iron-rich environment, promoting mucosal healing. A 2-way crossover intervention study will be conducted with FX856 supplementation in overweight and obese individuals who often exhibit mild gut inflammation by measuring faecal calprotectin and systemic inflammatory markers.
Trial Details
NCT Number NCT07253155
Lead Sponsor University of Ulster
Collaborators: Ferryx Limited
Conditions Gut Inflammation, Overweight and Obese Volunteers
Enrollment 100 participants
Start Date 2025-10-14
Primary Completion 2028-09-01 (estimated)
Study Completion 2028-09-01 (estimated)
Updated on ClinicalTrials.gov 2025-11-28