Transcultural Digital Solutions in Phase III Cardiac Rehabilitation

Multicenter Prospective Controlled Randomized Trial, open-label, in patients with atherosclerotic cardiovascular disease (ASCVD) (acute coronary syndrome or chronic coronary syndrome and ischemic heart failure) and an approved indication for cardiac rehabilitation (CR). Patients completing phase II CR will be randomized 1:1 to usual Phase-III care (standard care) versus standard care plus the Digitally-Enhanced Extended PrEvention \& Rehabilitation (DEEPER) package (intervention). Primary outcome is 6-month change in composite Life's Crucial 9 (LC9) (LE8 + PHQ-9).

NCT Number	NCT07252856
Lead Sponsor	Fondazione Don Carlo Gnocchi Onlus
Conditions	Heart Failure, Myocardial Infarction
Enrollment	306 participants
Start Date	2026-04-20
Primary Completion	2027-06-30 (estimated)
Study Completion	2027-07-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-30