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Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT)

Name: Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT) — clinical trial record (NCT07252544)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusNot Yet Recruiting

PhasePhase 3

SponsorBeijing Tiantan Hospital

Started2025-12-01

View on ClinicalTrials.gov ↗

Beijing Tiantan Hospital

280 trials monitored

See 4 trials at risk

Stroke

3,268 trials monitored

See 122 trials at risk

The goal of this multicenter, double-blind, 2×2 factorial randomized controlled trial is to evaluate the efficacy and safety of isosorbide mononitrate, butylphthalide, and their combination in reducing disability in patients with acute lacunar stroke.

Trial Details

NCT Number	NCT07252544
Lead Sponsor	Beijing Tiantan Hospital Collaborators: Shenzhen Second People's Hospital
Conditions	Stroke, Lacunar, Stroke, Acute Ischemic, Cerebral Small Vessel Diseases
Enrollment	3,156 participants
Start Date	2025-12-01
Primary Completion	2027-08-31 (estimated)
Study Completion	2028-02-29 (estimated)
Updated on ClinicalTrials.gov	2025-11-26