Clinical Trial

Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT)

Name: Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT) — clinical trial record (NCT07252544)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Not Yet Recruiting Phase 3

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Summary

The goal of this multicenter, double-blind, 2×2 factorial randomized controlled trial is to evaluate the efficacy and safety of isosorbide mononitrate, butylphthalide, and their combination in reducing disability in patients with acute lacunar stroke.

Trial Details

NCT Number	NCT07252544
Lead Sponsor	Beijing Tiantan Hospital Collaborators: Shenzhen Second People's Hospital
Conditions	Stroke, Lacunar, Stroke, Acute Ischemic, Cerebral Small Vessel Diseases
Enrollment	3,156 participants
Start Date	2025-12-01
Primary Completion	2027-08-31 (estimated)
Study Completion	2028-02-29 (estimated)
Updated on ClinicalTrials.gov	2025-11-26