Cognitive Rehabilitation in Post-stroke Cognitive Impairment

The goal of this 2-year, prospective, single-blind randomized clinical trial is to investigate: the efficacy in reducing the risk of cognitive impairment 6 months after stroke; the generalizability of cognitive reinforcement to real life, such as activities of daily living and quality of life; and the impact on cognitive performance. In the treatment group, feasibility, adherence, and satisfaction with the cognitive telerehabilitation program will also be evaluated. Participants will be adult patients with a diagnosis of ischemic or hemorrhagic stroke, within 5-21 days after onset. The main outcomes to be evaluated are: * diagnosis of cognitive impairment (primary outcome); * activities of daily living, quality of life, changes in frailty status, and cognitive efficiency (secondary outcomes). There will be two groups: a treatment group and a control group. Participants in the treatment group will undergo a cognitive telerehabilitation program of 40 hours over 8 weeks, while participants in the control group will be instructed to follow their standard care.

NCT Number	NCT07251517
Lead Sponsor	University of Florence Collaborators: University of Milan, University of Pavia
Conditions	Cognitive Impairment, Stroke Acute
Enrollment	86 participants
Start Date	2024-04-22
Primary Completion	2026-03-20 (estimated)
Study Completion	2026-03-20 (estimated)
Updated on ClinicalTrials.gov	2026-04-29