Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases. It is strongly associated with aging, cardiovascular risk factors (hypertension, diabetes, obesity), and is more prevalent in women than men. Patients with HFpEF frequently present with dyspnea, debilitating fatigue, poor quality of life, frequent hospitalizations, and high mortality rates. This study aims to evaluate the effects of a structured exercise program on cardiac function, skeletal muscle metabolism, functional capacity, and quality of life in patients with HFpEF, and to explore whether these benefits are mediated by circulating exerkines.

NCT Number	NCT07251361
Lead Sponsor	Universidad Pública de Navarra Collaborators: NavarraBiomed Biomedical Research Center, Centro de Investigación Médica Aplicada (CIMA), Complejo Hospitalario de Navarra, Fundación Instituto de Investigación Sanitaria de Navarra
Conditions	Heart Failure With Preserved Ejection Fraction (HFPEF)
Enrollment	150 participants
Start Date	2025-01-20
Primary Completion	2025-02-01 (estimated)
Study Completion	2026-12-20 (estimated)
Updated on ClinicalTrials.gov	2025-11-26