Treatment of Atypical Resistant Facial Pain

Facial pain in the trigeminal nerve region, which is not a migraine headache is often very persistent and difficult to treat. Research findings suggest that, similar to the mechanisms of migraine headache, the increased concentration of calcitonin gene-related peptide (CGRP) plays an important role in the mechanisms of facial pain. Therefore, the hypothesis is that intravenous administration of ACMP will similarly disrupt central sensitization in facial pain as it does in migraine headaches.

NCT Number	NCT07250984
Lead Sponsor	Alenka Spindler-Vesel
Conditions	Facial Pain
Enrollment	10 participants
Start Date	2025-11-03
Primary Completion	2026-11-03 (estimated)
Study Completion	2026-12-03 (estimated)
Updated on ClinicalTrials.gov	2025-12-22