Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression

The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators have designed a new psychological therapy tailored to address the symptoms that can be caused by difficult experiences in early life. These symptoms include low mood, emotional dysregulation, and distressing thoughts and beliefs related to difficult or traumatic experiences. The investigators would like to see if this new therapy helps people feel better. The investigators are also studying the biological changes that can occur as a result of early life adversity, and how this therapy may influence those changes. To do this, the investigators ask questions about participants' physical and mental health and take blood samples.

NCT Number	NCT07250893
Lead Sponsor	St. Joseph's Healthcare Hamilton Collaborators: Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Conditions	Depression - Major Depressive Disorder, Childhood Traumas
Enrollment	50 participants
Start Date	2025-10-25
Primary Completion	2027-08-15 (estimated)
Study Completion	2028-08-15 (estimated)
Updated on ClinicalTrials.gov	2026-07-14