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Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial

StatusActive, Not Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated November 25, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Minor Study First Submitted
The goal of this clinical trial is to determine the effectiveness of early use of hydrocortisone (since the diagnosis of shock) for its resolution within the first 72 hours in premature infants under 1,500 g. The main questions it aims to answer are: * Does the early use of hydrocortisone help solve shock in preterm infants under 1500 g faster than the standard treatment? * Does the early use of hydrocortisone help prevent death within the first seven days of presentation of shock in comparison to premature infants who receive regular treatment? Researchers will compare the early use of hydrocortisone plus the standard treatment to solve shock against just standard treatment. Participants will: * Be randomized to receive standard treatment for shock according to their neonatologist or this standard treatment plus hydrocortisone as soon as the diagnosis is done and treatment is started. * Be followed either until shock is solved or if they present death due to this event of shock.
Trial Details
NCT Number NCT07248761
Lead Sponsor Coordinación de Investigación en Salud, Mexico
Collaborators: Instituto Mexicano del Seguro Social
Conditions
(from sponsor)
Shock, Preterm Birth Complication, Preterm Intraventricular Hemorrhage, Asphyxia Perinatal, Distress Respiratory Syndrome, Hyperglycaemia (Non Diabetic), Neonatal Sepsis, Early-Onset, Neonatal Sepsis, Late-Onset +3 more
Related terms Enterocolitis, Necrotizing, Hyperglycemia, Intestinal Perforation, Neonatal Sepsis, Pulmonary Atelectasis, Shock
Enrollment 76 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov