Clinical Trial

Ozone Therapy for the Treatment of Oral Mucositis in Patients Undergoing Radio and Chemotherapy in the Head and Neck Region

Completed
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Summary
The present study aims to evaluate the effectiveness of a combined protocol of professional and at-home ozone therapy in the treatment of oral mucositis in patients undergoing radio- and/or chemotherapy. In-office treatment was performed using a medical ozone generator, while at-home therapy involved the daily application of high-concentration ozonated oil products. The study assessed the reduction in mucositis severity (WHO scale), decrease in pain (VAS scale), and improvement in patient-reported quality of life, with specific attention to nutrition, oral hygiene, and treatment adherence.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-11-20.
Status change: Recruiting → Completed 2026-01-23
Trial Details
NCT Number NCT07247799
Lead Sponsor Andrea Scribante
Conditions Oral Mucositis, Head and Neck Neoplasms
Enrollment 38 participants
Start Date 2025-09-01
Primary Completion 2026-01-10 (estimated)
Study Completion 2026-01-20 (estimated)
Updated on ClinicalTrials.gov 2026-01-27