Efficacy and Safety of CO₂ Laser Therapy Combined With Collagen Cream in Managing Vulvo-Vaginal Atrophy: A Randomized, Controlled Study on Symptom Relief and Microbiome Modulation

This study evaluated a new treatment for postmenopausal women suffering from vulvo-vaginal atrophy (VVA), a condition that causes dryness, burning, and pain. Researchers tested whether combining CO₂ laser therapy with a collagen-based cream could improve symptoms more effectively than laser treatment alone.

NCT Number	NCT07246616
Lead Sponsor	Institute for Social Security, Republic of San Marino
Conditions	Vulva; Atrophy
Enrollment	60 participants
Start Date	2024-06-01
Primary Completion	2024-10-01 (estimated)
Study Completion	2024-10-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-28