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Intermittent Preventive Treatment of Malaria in School-age Children to Decrease Community Transmission

Study acronym: CRITICal
StatusNot Yet Recruiting
PhasePhase 4
Started2026-09-28
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 30 days later Aug 31, 2029 → Sep 30, 2029
See other at-risk trials from University of California, San Francisco

Amendment history

2026-09-09
Study Status v3
Primary completion pushed: 2029-08-31 → 2029-09-30
Completion pushed: 2029-08-31 → 2029-09-30
Start date2026-08-01→2026-09-28
2026-05-05
Study Status v2
Primary completion pushed: 2029-05-31 → 2029-08-31
Completion pushed: 2029-05-31 → 2029-08-31
Start date2026-05-01→2026-08-01
2026-01-15
Study Status v1
Start date2025-12-01→2026-05-01
2025-11-17
Original filing
The CRITICal study aims to estimate the effectiveness of intermittent preventive treatment in school children (IPTsc) with dihydroartemisinin-piperaquine (DP) for reducing community level malaria burden. Given that school-aged children are the primary drivers of transmission, the study hypothesis is that IPTsc will reduce this infectious reservoir and thus the burden of malaria in persons of all ages in surrounding communities.
Trial Details
NCT Number NCT07246525
Lead Sponsor University of California, San Francisco
Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), Infectious Diseases Research Collaboration, Uganda, Ministry of Health, Uganda
Conditions Malaria
Enrollment 4,800 participants
Start Date 2026-09-28
Primary Completion 2029-09-30 (estimated)
Study Completion 2029-09-30 (estimated)
Updated on ClinicalTrials.gov 2026-09-11