A Comparative Analysis of Biomaterials for Retrograde Filling in Apical Surgery.

The aim of this study is to compare two biomaterials used for retrograde obturation during apical surgery. This surgery is indicated in healthy patients when root canal treatment (endodontics) has failed to eliminate a periapical lesion (a persistent infection in the root of the tooth). The main question it seeks to answer is: \- Is TotalFill® BC-RRM Fast Set Putty more effective than ProRoot® MTA in periapical surgery in terms of the degree of healing? The study will include patients who need this type of surgery and meet specific clinical criteria. Each patient will have one of the two materials applied as part of the standard surgical procedure. Subsequently, clinical and radiographic follow-up will be performed to assess the degree of healing of the periapical lesion with a 1-year follow-up.

NCT Number	NCT07246512
Lead Sponsor	University of Valencia
Conditions	Periapical Lesion
Enrollment	110 participants
Start Date	2024-02-08
Primary Completion	2026-01-20 (estimated)
Study Completion	2026-01-20 (estimated)
Updated on ClinicalTrials.gov	2026-07-13