Supplementation With Sirtuin Activators in Women With Increased Body Weight

The goal of this clinical trial is to learn if the six-month supplementation with sirtuin activators can affect metabolism in 40-to-65-year old women with increased body weight. The main questions it aims to answer are: Does sirtuin activators affect lipid and carbohydrate metabolism? Does sirtuin activators affect oxydative stress, immune functions and cell ageing? Researchers will compare sirtuin activators to a placebo (a look-alike substance that contains no drug) to see if drug sirtuin activators works to improve metabolic status. Participants will: Take sirtuin activators or a placebo every day for 6 months. Visit the university once every 3 months for checkups and tests.

NCT Number	NCT07245979
Lead Sponsor	Poznan University of Life Sciences Collaborators: Poznan University of Medical Sciences, NutroPharma
Conditions	Obesity & Overweight
Enrollment	120 participants
Start Date	2025-10-08
Primary Completion	2026-11-30 (estimated)
Study Completion	2027-03-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-22