Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.

The aim of this study is to test whether the addition of dextrose to perineural injections is superior to local anesthetic alone, as some initial data have indicated. To enhance the potential therapeutic effect, we will proceed to a 4-point injection technique, targeting 4 genicular nerves (superomedial, superolateral, inferomedial, recurrent peroneal genicular nerve) in a randomized controlled trial with two arms.

NCT Number	NCT07245121
Lead Sponsor	National and Kapodistrian University of Athens
Conditions	Chronic Pain, Perineural Analgesia, Prolotherapy, Knee Osteoarthritis
Enrollment	60 participants
Start Date	2025-11-24
Primary Completion	2026-12 (estimated)
Study Completion	2027-02 (estimated)
Updated on ClinicalTrials.gov	2025-12-02