Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation

This clinical investigation aims to assess how two different allogeneic dentin graft materials - one de-mineralized and the other mineralized - influence bone preservation following extraction of a single upper posterior tooth. A total of 45 patients will be randomly allocated into three equal groups: a socket-only spontaneous healing group (control), a de-mineralized dentin graft group, and a mineralized dentin graft group. Over a six-month period after extraction, measurements will be taken using CBCT to monitor changes in ridge width, height, and bone density. Secondary outcomes include patient-reported pain, postoperative swelling, satisfaction levels, width of keratinized tissue, and histomorphometric data from biopsy samples at implant placement. Findings from this trial may support evidence-based decisions in alveolar ridge preservation and help clinicians choose the most predictable grafting strategy before implant placement.

NCT Number	NCT07242313
Lead Sponsor	Kafrelsheikh University Collaborators: National Research Centre, Egypt
Conditions	Alveolar Ridge Preservation, Post Extraction Alveolar Bone Resorption
Enrollment	45 participants
Start Date	2025-10-21
Primary Completion	2026-08-01 (estimated)
Study Completion	2026-08-31 (estimated)
Updated on ClinicalTrials.gov	2025-11-24