Non-invasive Characterisation of Oral Carcinomas in Patients With Fanconi Anaemia

Patients with Fanconi anaemia have an increased risk of developing squamous cell carcinoma of the head and neck. In addition, their genetic vulnerability limits the use of genotoxic treatments such as radiotherapy and chemotherapy, due to increased exposure to severe toxicities. Less invasive diagnostic techniques, such as brush biopsies, which rely on cytological and ploidy analysis, offer the possibility of more systematic, comprehensive and less painful oral mapping, thereby facilitating earlier diagnosis.

NCT Number	NCT07242261
Lead Sponsor	Institut Jean-Godinot Collaborators: Université de Reims Champagne-Ardenne
Conditions	Fanconi Anaemia
Enrollment	115 participants
Start Date	2026-04-01
Primary Completion	2030-04-01 (estimated)
Study Completion	2030-10-01 (estimated)
Updated on ClinicalTrials.gov	2025-11-21