Conformal Ablative Radiotherapy in Older Women (CARMEN) With Breast Cancer Undergoing Non-Operative Management

This phase II study evaluates SABR as non-operative treatment for women aged 65+ with ER-positive, HER2-negative breast cancer ≤5 cm and no lymph node involvement. Eligible patients, including those previously on endocrine therapy, receive 5 SABR treatments, followed by monitoring of quality of life and assessment of treatment-related toxicity.

NCT Number	NCT07242118
Lead Sponsor	University of Kansas Medical Center
Conditions	Breast Cancer Female
Enrollment	18 participants
Start Date	2025-11-04
Primary Completion	2027-09 (estimated)
Study Completion	2027-10 (estimated)
Updated on ClinicalTrials.gov	2026-02-10