Cross-linked Hyaluronic Acid in Knee Osteoarthritis

Knee Osteoarthritis (Knee OA) leads to pain and loss of function, especially in recreational athletes. While hyaluronic acid (HA) injections are a common part of conservative treatment, comparative data on the efficacy of straight-chain (ST-HA) versus cross-linked (CL-HA) formulations remain limited. Therefore, the aim of this study was to compare the 6-month efficacy of a single dose of CL-HA versus two doses of ST-HA regarding pain, stiffness, and joint function in recreational athletes aged 50-70 with Kellgren-Lawrence grade 2-3 Knee OA refractory to pharmacological treatment.

NCT Number	NCT07241442
Lead Sponsor	Istanbul Medipol University Hospital
Conditions	Knee Osteoarthritis (Knee OA)
Enrollment	88 participants
Start Date	2021-01-02
Primary Completion	2024-12-31 (estimated)
Study Completion	2025-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-27