Clinical Trial

The Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE III) Study

Study acronym: DRIVE III
Active, Not Recruiting Phase 4
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Summary
This study will provide novel insight into the effects of repeat influenza vaccination with Flublok and FluMist on the strength and breadth of immune responses to influenza, the mechanisms underlying heterogeneity in vaccine response and vaccine failure, and biological factors that could explain variation in influenza vaccine effectiveness.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-11-16; most recent amendment 2026-05-14.
Status change: Recruiting → Active, Not Recruiting 2026-05-14
Trial Details
NCT Number NCT07240922
Lead Sponsor The University of Hong Kong
Conditions Influenza
Enrollment 600 participants
Start Date 2025-10-01
Primary Completion 2030-10-01 (estimated)
Study Completion 2030-10-01 (estimated)
Updated on ClinicalTrials.gov 2026-05-15