Comparison of FNB to EUS-CNB for Pancreatic Lesions

The primary aim of this study is to compare the tissue specimen quality and diagnostic accuracy of biopsies obtained with one puncture of a regular 22 FNB G needle and the motorized EUS CNB device of pancreatic lesions. The secondary aims are to compare the rate of blood contamination in the specimens obtained from biopsies of pancreatic lesions and the overall procedure duration. The hypothesis of this study is that the proportion of cases in which a single puncture of the lesion in question delivers adequate diagnostic tissue is higher with the motorized EUS CNB than with the 22 G FNB.

NCT Number	NCT07240818
Lead Sponsor	University of California, Davis
Conditions	Diagnosis of a Pancreaticobiliary Disorder, Biopsy, EUS Guided Biopsy
Enrollment	30 participants
Start Date	2026-07-01
Primary Completion	2026-11-01 (estimated)
Study Completion	2026-11-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-04