BMP Effect on Implant Stability and Marginal Bone Level After Immediate Placement

This randomized controlled clinical trial aims to evaluate the effect of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) on the stability and marginal bone level of dental implants following immediate placement. patients requiring extraction of unrestorable tooth in upper incisors or premolar region will be randomly assigned into two groups: the experimental group will receive immediate implant placement with rhBMP-2 application, while the control group will receive immediate implant placement without rhBMP-2. each group includes 16 immediate implants. Implant stability will be assessed using resonance frequency analysis (RFA) at baseline, and 16 weeks after implant placement. Marginal bone level changes will be evaluated radiographically using cone beam computed tomography (CBCT). The study aims to determine whether the use of rhBMP-2 enhances osseointegration and reduces marginal bone loss compared with conventional immediate implant placement.

NCT Number	NCT07240493
Lead Sponsor	Aya Adil Saeed
Conditions	Tooth Loss, Alveolar Ridge Resorption After Extraction, Tooth Extraction
Enrollment	24 participants
Start Date	2024-12-15
Primary Completion	2025-12-15 (estimated)
Study Completion	2026-01-15 (estimated)
Updated on ClinicalTrials.gov	2026-05-13