ATTRACT-52: Primary Care Cardiac Amyloidosis Screening in Ordu, Turkey

Cardiac amyloidosis is a progressive infiltrative cardiomyopathy, most commonly related to transthyretin (ATTR) misfolding. Although considered rare, emerging data suggest higher prevalence in specific regions, including the Black Sea area of Turkey. Early recognition improves outcomes. ATTRACT-52 is a prospective, observational, non-interventional screening study in primary care (family medicine centers) across Ordu province. Adults ≥65 years with cardiac or musculoskeletal "red flags" will be screened; those meeting high-suspicion criteria will undergo NT-proBNP/BNP testing at the primary care level to aid risk stratification prior to referral for confirmatory diagnostics.

NCT Number	NCT07238426
Lead Sponsor	Kotyora Family Medicine Health Management and Education Association Collaborators: Ordu University, Faculty of Medicine - Department of Cardiology (Academic Collaborator), Ordu Provincial Health Directorate - Family Medicine Network (Regional Collaborator)
Conditions	Cardiac Amyloidosis, Transthyretin Amyloidosis
Enrollment	800 participants
Start Date	2025-12-01
Primary Completion	2026-10-31 (estimated)
Study Completion	2026-10-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-25