REAl World Dementia OUTcomes: Observational Study

READ-OUT observational study will investigate blood-based biomarkers for dementia in real-world clinical settings. This 3-year observational study will include 3165 people, males or females aged 45 years or older, with cognitive impairment of any severity. Participants provide blood samples and complete questionnaires about quality of life and healthcare use, with some having additional follow-ups at 2 weeks and 1 year. The study will assess reliability and accuracy of blood tests in diagnosing dementia.

NCT Number	NCT07238049
Lead Sponsor	University of Oxford Collaborators: University of Cambridge, University of Edinburgh, Greater Manchester Mental Health NHS Foundation Trust, University of Bristol, Queen Mary University of London, West London NHS Trust, University College, London, Imperial College London, Aneurin Bevan University Health Board, Queen's University, Belfast
Conditions	Alzheimer Disease (AD), Mild Cognitive Impairment (MCI), Dementia
Enrollment	3,165 participants
Start Date	2024-11-01
Primary Completion	2029-10-31 (estimated)
Study Completion	2029-10-31 (estimated)
Updated on ClinicalTrials.gov	2025-11-20