Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus

People with type 2 diabetes have a much higher risk of heart disease. One common problem is when the blood vessels that supply the heart become narrowed or blocked by fatty deposits, called plaque. This makes it harder for blood to reach the heart and can lead to serious problems such as chest pain, heart attacks, or even death. This study will follow people with type 2 diabetes who have already had a special heart scan called a coronary CT angiography. This scan takes detailed pictures of the heart's blood vessels. The goal is to understand how heart disease changes over time in people with type 2 diabetes, by looking at repeat scans and other health information. By learning more about how plaque builds up or gets worse, researchers hope to find better ways to identify which patients are most at risk for future heart problems.

NCT Number	NCT07237685
Lead Sponsor	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Collaborators: Horizon Innovative Health Initiative, Novo Nordisk A/S, INSTITUTO DE INVESTIGACION BIOMEDICA DE SALAMANCA (IBSAL), Cardiology Centers of the Netherlands
Conditions	Type 2 Diabetes, Coronary Artery Disease (CAD), Atherosclerosis Cardiovascular Disease
Enrollment	1,000 participants
Start Date	2025-06-06
Primary Completion	2026-10-01 (estimated)
Study Completion	2036-10-01 (estimated)
Updated on ClinicalTrials.gov	2025-11-20