The Effect of Different Intracanal Medicaments on Periapical Lesion Healing

This study is planned to evaluate the effects of two different intracanal medicaments-calcium hydroxide and diclofenac sodium-on periapical healing following endodontic retreatment. Fifty-four patients will be included and randomly assigned into two groups according to the type of medicament used. All procedures will be performed by a single experienced endodontist under standardized clinical conditions. Periapical lesion healing will be assessed radiographically at baseline and after 12 months using fractal analysis to quantitatively evaluate bone regeneration. The primary outcome will be the change in the fractal dimension values between the initial and follow-up radiographs.

NCT Number	NCT07237620
Lead Sponsor	Mustafa Kemal University
Conditions	Periapical Lesion Healing, Apical Periodontitis
Enrollment	60 participants
Start Date	2025-09-15
Primary Completion	2026-09-01 (estimated)
Study Completion	2027-04-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-08