Non-Invasive Diagnosis and Monitoring of Cardiac Masses by Liquid Biopsy

This is a nonprofit, observational, prospective and retrospective,multicenter study in a population of young and adult patients ≥12 years with a diagnosis of a cardiac mass. The study will include both patients with masses of unknown pathological diagnosis and patients with a known histology of benign or malignant tumors. We predict a case-control allocation ratio of 1:1 between cardiac malignant tumors and benign lesions. Peripheral blood will be collected at participating centers during routine venipuncture,processed and then shipped for liquid biopsy ctDNA NGS analyses. If available, in malignant cases, matched tumor tissue samples collected as per clinical practice solid biopsies or surgery will be used for analyses. Longitudinal tracking through serial blood draws could be performed in selected cases of patients with cardiac malignancies who receive cancer treatment

NCT Number	NCT07235865
Lead Sponsor	Niguarda Hospital
Conditions	Cardiac Masses
Enrollment	26 participants
Start Date	2024-07-25
Primary Completion	2025-01-01 (estimated)
Study Completion	2026-12-25 (estimated)
Updated on ClinicalTrials.gov	2026-04-15