Functional Magnetic Stimulation (FMS) for Bone Marrow Edema in Athletes

This randomized controlled trial evaluates whether Functional Magnetic Stimulation (FMS) can provide additional benefits when combined with a structured physiotherapy rehabilitation program in athletes with MRI-confirmed tibial bone stress injury and associated bone marrow edema. A total of 40 athletes with Fredericson grade 2 or 3 lesions are allocated to either a combined intervention group receiving FMS plus rehabilitation or a control group receiving rehabilitation alone. The intervention period lasts four weeks. Participants in both groups follow the same load-based rehabilitation program, while those in the FMS group also receive eight 30-minute FMS sessions. Assessments are performed at baseline, after the four-week intervention, and at 16 weeks. The evaluated outcomes include activity-related tibial pain, lower-limb functional ability, MRI-measured bone marrow edema extent, and Fredericson MRI grade. The purpose of the study is to examine whether adding FMS to standardized rehabilitation leads to greater clinical, functional, and MRI-derived improvement compared with rehabilitation alone.

NCT Number	NCT07234084
Lead Sponsor	International Hellenic University
Conditions	Bone Marrow Edema
Enrollment	40 participants
Start Date	2025-12-01
Primary Completion	2026-06-29 (estimated)
Study Completion	2026-06-29 (estimated)
Updated on ClinicalTrials.gov	2026-07-01