MS Synchronous vs Asynchronous Exercise Study

This randomized controlled study aims to compare the effects of synchronous and asynchronous exercise programs on individuals diagnosed with relapsing-remitting multiple sclerosis (RRMS). Participants meeting the inclusion criteria (EDSS score between 2 and 5.5, aged 18-55) were randomly assigned to either the Synchronous Exercise Group (SEG) or the Asynchronous Exercise Group (ASEG). The synchronous program was delivered via live online sessions using Google Meet and WhatsApp video calls, while the asynchronous program consisted of pre-recorded exercise videos accessible to participants. Both programs included structured exercises focusing on functional capacity, muscle strength, fatigue, independence, and quality of life. The sample size was determined using G\*Power software based on previous studies in individuals with multiple sclerosis, targeting a total of 16. Statistical analyses will be conducted using SPSS 26.0. Parametric and non-parametric tests will be used depending on data distribution, with significance set at p \< 0.05. The study seeks to improve accessibility to exercise programs for MS patients and provide evidence for the efficacy of remotely delivered synchronous versus asynchronous rehabilitation models.

NCT Number	NCT07233902
Lead Sponsor	Yeditepe University Collaborators: The Scientific and Technological Research Council of Turkey
Conditions	Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting
Enrollment	16 participants
Start Date	2025-04-01
Primary Completion	2025-10-01 (estimated)
Study Completion	2025-10-29 (estimated)
Updated on ClinicalTrials.gov	2026-01-21