Comparison of Pain Between Supraperiosteal Injection of Dexamethasone Versus Placebo on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis

This randomized controlled trial aims to compare the effectiveness of supra periosteal injection of dexamethasone versus placebo in reducing post operative pain in teeth diagnosed with symptomatic irreversible pulpitis. A total of 44 patients will be randomly assigned into two groups: Group A will receive a supra periosteal injection of dexamethasone(4mg/ml), and Group B will receive a similar injection of normal saline as placebo. post operative pain will be assessed at 6hr,24hr and 48hr using a VAS Analogue Scale, with the final outcome measured at 24hrs. the study will help determine whether local dexamethasone injection is effective in minimizing postoperative pain

NCT Number	NCT07233564
Lead Sponsor	College of Physicians and Surgeons Pakistan
Conditions	Irreversible Pulpitis
Enrollment	44 participants
Start Date	2025-07-15
Primary Completion	2026-02-01 (estimated)
Study Completion	2026-02-15 (estimated)
Updated on ClinicalTrials.gov	2025-11-18