M-TAPA Block for Analgesia After Open-Heart Surgery

Postoperative pain following open-heart surgery is primarily caused by median sternotomy, although additional contributors include costovertebral joint stress related to sternal retraction and the presence of chest wall and mediastinal drains during the postoperative period. This pain is often severe, especially in the early postoperative hours, making effective management both challenging and essential. Insufficient pain control frequently necessitates high doses of opioids, which may lead to adverse effects such as nausea, vomiting, respiratory complications, and postoperative delirium. Excessive use of anesthetic agents or opioids can also delay extubation and prolong the process of weaning from mechanical ventilation. The modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA) is a regional anesthesia technique performed beneath the costal margin between the internal oblique and transversus abdominis muscles. It provides broad dermatomal coverage, extending approximately from the upper thoracic to the lower thoracic and upper lumbar segments. This study aims to evaluate the postoperative analgesic effectiveness of combining the M-TAPA block with a parasternal block in patients undergoing open-heart surgery.

NCT Number	NCT07232979
Lead Sponsor	Bursa City Hospital Collaborators: Ulusoy, Emre, M.D.
Conditions	Postoperative Pain, Acute Pain
Enrollment	80 participants
Start Date	2026-01-15
Primary Completion	2026-04-15 (estimated)
Study Completion	2026-04-15 (estimated)
Updated on ClinicalTrials.gov	2025-11-19