Biomarkers and Respiratory Omics as New CHildren Opportunities - Study of Clinical Outcomes and Predictivity Evaluation

The goal of this observational study is to improve the identification of biomarkers that predict disease progression and to assess the effectiveness of current therapies in children with asthma and protracted bacterial bronchitis. The main aim of the study is to evaluate the microbiome composition and diversity, cellular composition, and metabolomic profile. In addition, to assess their correlation on subsequent treatment and disease course in children with asthma, protracted bacterial bronchitis, and in those receiving inhaled glucocorticosteroids without a diagnosis of asthma. Participants will undergo fiberoptic bronchoscopy. During bronchoscopy, the performing physician will collect Bronchoalveolar lavage fluid samples for metagenomic and metabolomic analysis, as well as mucosal biopsies for histopathological evaluation.

NCT Number	NCT07232550
Lead Sponsor	Medical University of Warsaw Collaborators: Medical University of Lodz, Medical University of Bialystok
Conditions	Asthma in Children, Protracted Bacterial Bronchitis, Chronic Cough
Enrollment	160 participants
Start Date	2026-03-06
Primary Completion	2035-12 (estimated)
Study Completion	2035-12 (estimated)
Updated on ClinicalTrials.gov	2026-07-30