Clinical Trial

Mechanisms Of Orbitofrontal Stimulation in Depression

Study acronym: MOOD
Recruiting
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Summary
The orbitofrontal cortex (OFC), a region involved in emotional regulation, decision making, and reward processing, is a key area linked to antidepressant response. This study tests whether noninvasive stimulation of the OFC using transcranial magnetic stimulation (TMS) can improve depressive symptoms. TMS uses magnetic fields generated by a coil placed next to the scalp to alter brain activity.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-11-13.
Status change: Not Yet Recruiting → Recruiting 2026-05-11
Trial Details
NCT Number NCT07230990
Lead Sponsor Subha Subramanian
Conditions Major Depressive Disorder (MDD)
Enrollment 80 participants
Start Date 2026-04-15
Primary Completion 2030-12 (estimated)
Study Completion 2030-12 (estimated)
Updated on ClinicalTrials.gov 2026-05-14