Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.

The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults. The main questions it aims to answer are: Does addition of hydroxychloroquine reduce physical complaints? Researchers will compare hydroxychloroquine to a placebo (a look-alike substance that contains no drug) to see if hydroxychloroquine works to treat Lyme borreliosis. Participants will: Take hydroxychloroquine or a placebo two times a day during 28 days. Visit the clinic 4 times in one year for checkups and tests.

NCT Number	NCT07230028
Lead Sponsor	Radboud University Medical Center Collaborators: Ministerie van Volksgezondheid, Welzijn en Sport
Conditions	Lyme Borreliosis, Nervous System
Enrollment	50 participants
Start Date	2026-03-01
Primary Completion	2026-11-01 (estimated)
Study Completion	2027-11-01 (estimated)
Updated on ClinicalTrials.gov	2025-11-17