Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury

Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life. The factors that lead to the heighten and accelerated risk of heart attacks and strokes in adults living with SCI remain poorly understood. The investigators aim to uncover why this happens and find ways to prevent it. Our research focuses on how important cells which line blood vessels, called endothelial cells, function after SCI. The investigators test endothelial function in live conscious people with SCI. The investigators also study signaling molecules endothelial cells release called endothelial cell derived microvesicles (EMVs), which the investigators can measure in blood to tell us the health of endothelial cells. By using these rigorous tests of vascular function, the investigators have determined that endothelial cells appear dysfunctional after SCI. The investigators also know that many men with SCI have low testosterone levels. Our team has studied testosterone's effects on endothelial dysfunction and believe low testosterone may be contributing to endothelial dysfunction after SCI. By understanding these mechanisms, the investigators hope to improve the lives of those living with SCI and reduce their risk for heart attacks and strokes. The investigators propose to study the influence of testosterone on endothelial function by using state-of-the-art clinical and laboratory experiments to assess endothelial function in men with SCI with low and normal testosterone levels.

NCT Number	NCT07227740
Lead Sponsor	Craig Hospital Collaborators: University of Colorado, Boulder, Denver Health and Hospital Authority, University of Colorado, Denver
Conditions	Spinal Cord Injuries, Endothelial Dysfunction, Testosterone Deficiency
Enrollment	48 participants
Start Date	2025-07-15
Primary Completion	2028-07-14 (estimated)
Study Completion	2028-07-14 (estimated)
Updated on ClinicalTrials.gov	2025-11-21