Clinical Trial

Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma

Study acronym: PNOC041
Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
This is a multi-site study of the pharmacodynamic effects and efficacy of metformin in children and young adults with recurrent or progressive Posterior Fossa Group A (PFA) ependymoma.
Protocol Amendment History 3 changes
notable Trial sites expanded: 5 -> 10 locations 2026-08-15
critical Recruitment opened 2026-05-08
critical Trial status changed: Recruiting → Not Yet Recruiting 2026-04-09
Trial Details
NCT Number NCT07226453
Lead Sponsor University of California, San Francisco
Collaborators: The Lilabean Foundation, Inc., Pediatric Neuro-Oncology Consortium
Conditions Posterior Fossa Ependymal Tumor
Enrollment 30 participants
Start Date 2026-05-05
Primary Completion 2028-04-30 (estimated)
Study Completion 2030-03-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-14