Clinical Trial

Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)

Study acronym: ENGINE
Recruiting Phase 1/2
View on ClinicalTrials.gov →
Summary
This randomized, placebo-controlled crossover trial will test the feasibility and acceptability of using colesevelam in male firefighters with high per- and polyfluoroalkyl substances (PFAS) exposure. This trial will also explore whether colesevelam lowers blood PFAS levels and urine environmental toxicant and mold mycotoxin levels.
Protocol Amendment History 1 change
notable Enrollment increased: 40 -> 50 participants 2026-04-25
Trial Details
NCT Number NCT07226440
Lead Sponsor University of California, San Francisco
Conditions Toxicant Exposure, Firefighter, Occupational Exposure to Chemicals
Enrollment 50 participants
Start Date 2026-03-01
Primary Completion 2028-12 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2026-04-24