Clinical Trial

The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV

Recruiting
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Summary
The goal of this clinical trial is to learn if depression treatment improves insulin resistance, or how the body uses insulin to lower blood sugar, in people with HIV on HIV treatment. Researchers will compare an internet-based (online) depression treatment program called cognitive behavioral therapy with depression education. In the online group, participants will undergo 9 weekly treatment sessions. The education group will receive learning materials about depression and will be monitored every month. All participants will have 4 study visits over 12 months.
Protocol Amendment History 3 changes
notable Primary completion pushed: 2030-12-31 -> 2031-06-30 2026-06-03
minor Completion pushed: 2030-12-31 -> 2031-06-30 2026-06-03
critical Recruitment opened 2026-04-16
Trial Details
NCT Number NCT07226128
Lead Sponsor Indiana University
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions HIV, Depression in Adults, Insulin Resistance, Cognitive Behavior Therapy
Enrollment 150 participants
Start Date 2026-04-10
Primary Completion 2031-06-30 (estimated)
Study Completion 2031-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-10