Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

The goal of this one-arm clinical trial is to determine whether participants with mild cognitive impairment (MCI) can successfully navigate a virtual reality (VR) maze. The VR maze is designed as a training tool aimed at improving participants' spatial navigation abilities. Main Aims: 1. To determine whether at least 70% of older adults enrolled in the study can complete twenty-four 50-minute training sessions over a 4-month period. 2. To assess whether combining virtual reality with EEG recordings can be used to measure brain activation and changes in brain activation associated with spatial navigation learning. Participants will: 1. Walk in an open, unobstructed space while wearing VR goggles. 2. Explore up to fifty different virtual mazes in sequence and attempt to find their way through each one.

NCT Number	NCT07225400
Lead Sponsor	Albert Einstein College of Medicine Collaborators: National Institute on Aging (NIA)
Conditions	Mild Cognitive Impairment (MCI)
Enrollment	30 participants
Start Date	2026-10-01
Primary Completion	2027-12-23 (estimated)
Study Completion	2027-12-23 (estimated)
Updated on ClinicalTrials.gov	2026-08-10