Recovery of Physical Function After Critical Illness In Older Adults

The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially. Patients will be enrolled after life-saving modalities have been weaned near hospital discharge. Patients will participate in testing at baseline, 3-, 6-, 12-, and 24-months after hospital discharge. In a subset of patients (n = 18), muscle biopsies will be performed at baseline and then repeated once at either 12- or 24-months after hospital discharge.

NCT Number	NCT07225257
Lead Sponsor	University of Kentucky
Conditions	Sepsis, Acute Lung Injury(ALI)
Enrollment	150 participants
Start Date	2026-03-11
Primary Completion	2030-06-01 (estimated)
Study Completion	2031-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-28