The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold

The goal of this clinical trial is to determine whether a ketone supplement with carbohydrates extends time to fatigue during cycling compared with a carbohydrate-only supplement in healthy, trained cyclists aged 18-55. The main questions it aims to answer are: Is the time to fatigue increased with ketone supplementation and carbohydrates compared to carbohydrates alone? Will ketone supplementation with carbohydrates produce lower blood lactate concentrations compared to carbohydrates alone? Participants will: * Perform a staged maximal cycling exercise test on a stationary bicycle. * Finger prick to obtain a drop of blood for lactate measurements. * Wear a mask connected to a metabolic cart to measure breath contents. * Perform a cycling exercise test to fatigue for at least one hour. * Consume either a ketone supplement with carbohydrates or a carbohydrate supplement during the exercise at least 4 times. * Finger prick to obtain a drop of blood to measure blood lactate, ketones, and glucose.

NCT Number	NCT07224282
Lead Sponsor	University of Oklahoma
Conditions	Exogenous Ketosis
Enrollment	15 participants
Start Date	2025-11-17
Primary Completion	2026-03-09 (estimated)
Study Completion	2026-05-03 (estimated)
Updated on ClinicalTrials.gov	2025-11-04