Clinical Trial

Impact of Intraoperative Oxygenation Practices on Patient Outcomes

Study acronym: IntraOp Ox
Recruiting
View on ClinicalTrials.gov →
Summary
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-10-31; most recent amendment 2026-06-09.
Status change: Not Yet Recruiting → Recruiting 2025-12-01
Trial Details
NCT Number NCT07224243
Lead Sponsor Frederic T Billings IV
Collaborators: Multicenter Perioperative Outcomes Group, University of Michigan, The Association of University Anesthesiologists
Conditions Surgeries Undergoing General Anesthesia
Enrollment 54,000 participants
Start Date 2025-12-01
Primary Completion 2028-02 (estimated)
Study Completion 2028-04 (estimated)
Updated on ClinicalTrials.gov 2026-06-10