Clinical Trial

A Superiority Trial of Radiofrequency Ablation for Low Back Pain

Study acronym: ASTRAL
Recruiting
View on ClinicalTrials.gov →
Summary
The purpose of the ASTRAL Study is to evaluate the effectiveness of LRFA (Lumbar radiofrequency ablation) against a control procedure. The ASTRAL Study will enroll individuals with chronic low back pain (CLBP) and randomly assign them to one of three groups: lumbar radiofrequency ablation using conventional electrodes placed parallel to the medial branch nerves (LRFA-C), lumbar radiofrequency ablation using multi-tined electrodes placed perpendicular to the medial branch nerves (LRFA-M), or a simulated radiofrequency ablation procedure.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-10-27; most recent amendment 2026-02-05.
Status change: Not Yet Recruiting → Recruiting 2025-12-22
Trial Details
NCT Number NCT07222462
Lead Sponsor University of Washington
Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions Chronic Low Back Pain (CLBP)
Enrollment 300 participants
Start Date 2026-02-04
Primary Completion 2029-03 (estimated)
Study Completion 2029-08 (estimated)
Updated on ClinicalTrials.gov 2026-02-09