Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study

This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD. It builds on an ongoing study testing different combinations of THC and CBD in 200 veterans. In this project, up to 100 veterans will complete brain scans before and after 12 weeks of cannabis administration to see how the brain changes over time. The scans will measure a marker sensitive to neuroinflammatory state, brain communication, and activity during thinking and emotion tasks. By linking these brain changes to improvements in PTSD symptoms, suicidal thoughts, and quality of life, this study may help identify which veterans benefit most from cannabis-based treatments and support more personalized care for PTSD.

NCT Number	NCT07222306
Lead Sponsor	Wayne State University Collaborators: Barbara Ann Karmanos Cancer Institute
Conditions	PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
Enrollment	100 participants
Start Date	2026-01-01
Primary Completion	2030-08-31 (estimated)
Study Completion	2030-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-06