Melatonin for the Treatment of DEE-SWAS

The goal of this study is to learn if melatonin, a naturally produced substance, can help to treat some of the symptoms of DEE-SWAS, a type of epilepsy that causes children to lose skills and development. It will look at doses of melatonin that are higher than most people use. The study will look at the safety of melatonin in patients with DEE-SWAS The study will look at the ways melatonin affects abnormal brain activity on a study called an EEG. The study will look at the ways melatonin affects normal brain activity that occurs in sleep.

NCT Number	NCT07221968
Lead Sponsor	Hugo W. Moser Research Institute at Kennedy Krieger, Inc. Collaborators: Johns Hopkins University
Conditions	CSWS, Developmental and/or Epileptic Encephalopathies, Electrical Status Epilepticus in Sleep
Enrollment	3 participants
Start Date	2026-07-01
Primary Completion	2028-07-01 (estimated)
Study Completion	2028-12-30 (estimated)
Updated on ClinicalTrials.gov	2025-10-30