Clinical Trial

Integrating Project YES! With WHO-Endorsed Mental Health Approaches Among Youth Living With HIV

Completed
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Summary
The proposed study will address the intersecting stigmas of HIV, violence and depression among adolescents and young adults (15-24) living with HIV (AYALHIV) in Zambia. The study will integrate a WHO-endorsed mental health approach into an existing HIV-stigma-reducing intervention, and refine measures of internalized and intersecting stigmas, to create and test the feasibility of Project YES+- a combined youth peer mentoring and lay mental health intervention. This research aims to shift HIV care and treatment for AYALHIV by addressing the multiple internalized and intersecting stigmas that impeded antiretroviral adherence and HIV viral suppression.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-10-24; most recent amendment 2026-06-29.
Status change: Recruiting → Completed 2026-06-29
Status change: Not Yet Recruiting → Recruiting 2025-11-21
Trial Details
NCT Number NCT07221201
Lead Sponsor Johns Hopkins Bloomberg School of Public Health
Collaborators: Fogarty International Center of the National Institute of Health, Arthur Davison Children's Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions HIV - Human Immunodeficiency Virus, Mental Health, Anxiety, Depression in Adolescence, Stigma
Enrollment 323 participants
Start Date 2025-10-25
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-30