Clinical Trial

Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty

Enrolling by Invitation Phase 4
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Summary
The purpose this study is determine whether postoperative oral dosage of suzetrigine is effective at controlling postoperative pain and reducing analgesic requirements following primary total knee arthroplasty (TKA) versus a control group of TKA patients receiving postoperative Oxycodone.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-10-20; most recent amendment 2026-04-28.
Status change: Not Yet Recruiting → Enrolling by Invitation 2026-04-28
Trial Details
NCT Number NCT07219888
Lead Sponsor University of Louisville
Conditions Osteoarthritis (OA) of the Knee
Enrollment 140 participants
Start Date 2026-02-09
Primary Completion 2026-12-31 (estimated)
Study Completion 2027-04-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-04