Clinical Trial

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

Study acronym: MOTION
Recruiting Phase 3
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Summary
This is a multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of intra-articular administration of PTP-001 (MOTYS) for the treatment of knee osteoarthritis. The purpose of the trial is to evaluate the efficacy, safety, and tolerability of a single intra-articular injection of PTP-001 compared to placebo over a 52-week period in participants with radiographic and symptomatic knee OA.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-10-21; most recent amendment 2026-04-28.
Trial Details
NCT Number NCT07219771
Lead Sponsor Doron Therapeutics Inc.
Collaborators: Novotech (Australia) Pty Limited
Conditions Knee Osteoarthritis
Enrollment 260 participants
Start Date 2025-10-14
Primary Completion 2027-04 (estimated)
Study Completion 2027-10 (estimated)
Updated on ClinicalTrials.gov 2026-04-29