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Intervention for Communication Quality of Life in Primary Progressive Aphasia

Study acronym: Multi-PA
StatusRecruiting
PhaseNot applicable
SponsorMaya Henry
Started
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Record History

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  1. Notable Lead sponsor: University of Texas at Austin to Maya Henryv4 Show 6 more changesShow less
    • Primary endpoints revised (4)
    • Enrollment target: 25 to 30
    • Start date changed from estimate of Jan 3, 2026 to Apr 1, 2026
    • Interventions: Multicomponent Lexical Retrieval Training (Behavioral), Multicomponent Video Implemented Script Training in Aphasia (Behavioral) to Multicomponent Lexical Retrieval Cascade Training (Behavioral), Multicomponent Video Implemented Script Training in Aphasia (Behavioral)
    • Eligibility criteria expanded, about 6 words
    • Secondary endpoints: details revised at 5 of 5 entries
  2. Minor Secondary endpoints revised (5)v3
  3. Minor Eligibility criteria shortened, about 56 words
    • Secondary endpoints revised (5)
    v2
  4. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
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The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish. The main questions the study aims to answer are: * Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners? * Do participants with PPA and study partners find treatment beneficial? * What patterns of treatment response are seen in participants? * Which outcome measures are most useful for evaluating changes in communication and quality of life? Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life. Participants will: * Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period. * Receive education and communication training together with their partner. * Complete speech, language, and cognitive assessments. * Complete questionnaires about communication abilities, daily functioning, and quality of life.
Trial Details
NCT Number NCT07219680
Lead Sponsor Maya Henry
Collaborators: National Institutes of Health (NIH), National Institute on Aging (NIA)
Conditions
(from sponsor)
Primary Progressive Aphasia(PPA), Semantic Dementia, Logopenic Progressive Aphasia (LPA), Nonfluent Aphasia, Progressive, Progressive Aphasia, Semantic Variant Primary Progressive Aphasia (svPPA), Semantic Aphasia, Logopenic Variant Primary Progressive Aphasia +4 more
Related terms Aphasia, Aphasia, Primary Progressive, Frontotemporal Dementia, Neurodegenerative Diseases, Primary Progressive Nonfluent Aphasia
Enrollment 30 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov