Clinical Trial

Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use

Not Yet Recruiting Phase 1

Summary

The purpose of this study is to understand how kratom affects people. In this study, kratom will be compared with another substance and a placebo (an inactive substance). Researchers will also study how the substances move through and affect the body. This includes examining how the body absorbs, processes, and eliminates the drug (pharmacokinetics), as well as how the drug affects the body and how it may make you feel (pharmacodynamics). The information collected will help researchers better understand the effects and potential risks of kratom.

Protocol Amendment History 1 amendment

This ClinicalTrials.gov record has been amended once since 2025-10-16.

Trial Details

NCT Number	NCT07218549
Lead Sponsor	Christopher D. Verrico Collaborators: Baylor College of Medicine
Conditions	Opioid Use, Substance Use Disorders, Opioid Analgesia
Enrollment	72 participants
Start Date	2026-09-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-30