A Trial to Test Intermittent Deep Brain Stimulation of Nucleus Basalis of Meynert to Treat Alzheimers.

The purpose of this study is to test a new procedure to treat Alzheimer's disease. The procedure is called intermittent Deep Brain Stimulation (DBS) of the nucleus basalis of Meynert. There will be up to six participants enrolled at Wellstar MCG Memory Clinic. There will be another six participants similarly enrolled to act as a control group that does not receive DBS. This second group will document the course of progression of Alzheimer's disease under the normal standard of care. The main goal of the study is to determine if DBS can sustain or improve cognition in Alzheimer's disease for at least two years. Participant data, with identifying information removed, may be shared with online repositories for comparison with trials with similar subjects.

NCT Number	NCT07218081
Lead Sponsor	Augusta University
Conditions	Alzheimer Dementia (AD)
Enrollment	12 participants
Start Date	2026-02-01
Primary Completion	2028-11-01 (estimated)
Study Completion	2028-11 (estimated)
Updated on ClinicalTrials.gov	2026-01-07